Disease table of AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME OMIM ID: 601859

Gene-disease associations table

GeneAssociated with AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
FASClinVar, OMIM, HUMSAVARHGNC link10q23.311601859
FASLGClinVar, OMIM, HUMSAVARHGNC link1q24.32601859, 211980

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
EGR1NO90ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG2FAS, FASLG
JUNNO155PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC2FAS, FASLG
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62FAS, FASLG
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62FAS, FASLG
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12FAS, FASLG
ATF2NO31FN1, ATF3, PLAU, IMPDH2, IFNG, PLAT, PTGS2, APOC3, NOS3, FAS, MAP3K1, RETN, TNF, PCK2, CYP11B1, CDKN1A, IFNB1, TGFB2, PCK1, JUN, RELA, DUSP10, DUSP1, ITGB8, MMP2, INS, POLB, ST3GAL5, CYP11B2, CCND1, FASLG2FAS, FASLG
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
FASYES25ATM, NFYA, TP53, ATF2, PURA, FOS, SP1, EGR1, GLI2, STAT1, GLI1, YBX1, HDAC1, NFYB, NFYC, JUN, TFAP2A, RELA, NFKB1, HDGF, STAT3, SREBF1, SREBF2, NFKBIA, YY10
FASLGYES17SP1, MYC, CREM, EGR1, NFKB1, IRF1, EGR2, CEBPB, MAX, JUN, NR4A1, ATF2, RELA, CIITA, FOXO3, PPARG, PDCD110
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
FASFASLGYes15ARHGDIA, MAPK8, CASP10, EZR, FAS, RHOA, CASP8, TNFRSF10B, TNFRSF1A, CFLAR, LCK, MSN, FYN, BID, FADD

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
FASFASLGthey interact as TF and regulated geneThey are a cytokine and its transcription factor. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Proteoglycans in cancerhsa052055.022FAS, FASLG
Natural killer cell mediated cytotoxicityhsa046505.532FAS, FASLG
Autoimmune thyroid diseasehsa053206.622FAS, FASLG
MAPK signaling pathwayhsa040104.632FAS, FASLG
Allograft rejectionhsa053306.912FAS, FASLG
Graft-versus-host diseasehsa053326.842FAS, FASLG
Chagas disease (American trypanosomiasis)hsa051425.992FAS, FASLG
African trypanosomiasishsa051437.682FAS, FASLG
Non-alcoholic fatty liver disease (NAFLD)hsa049325.512FAS, FASLG
Herpes simplex infectionhsa051685.082FAS, FASLG
Measleshsa051625.62FAS, FASLG
Apoptosishsa042106.232FAS, FASLG
Influenza Ahsa051645.212FAS, FASLG
Type I diabetes mellitushsa049406.792FAS, FASLG
Pathways in cancerhsa052003.982FAS, FASLG
Hepatitis Bhsa051615.522FAS, FASLG
Cytokine-cytokine receptor interactionhsa040604.672FAS, FASLG

NET-GE enrichment

Term New enriched termICP valueGenes
Influenza A (hsa05164) -5.210.029FAS, FASLG
Proteoglycans in cancer (hsa05205) -5.020.038FAS, FASLG
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.019FAS, FASLG
Rheumatoid arthritis (hsa05323) NEW6.050.041FAS, FASLG
Autoimmune thyroid disease (hsa05320) -6.620.004FAS, FASLG
Allograft rejection (hsa05330) -6.910.005FAS, FASLG
Graft-versus-host disease (hsa05332) -6.840.006FAS, FASLG
Chagas disease (American trypanosomiasis) (hsa05142) -5.990.01FAS, FASLG
African trypanosomiasis (hsa05143) -7.680.001FAS, FASLG
Herpes simplex infection (hsa05168) -5.080.035FAS, FASLG
Non-alcoholic fatty liver disease (NAFLD) (hsa04932) -5.510.019FAS, FASLG
Apoptosis (hsa04210) -6.230.007FAS, FASLG
TNF signaling pathway (hsa04668) NEW5.960.046FAS, FASLG
Type I diabetes mellitus (hsa04940) -6.790.01FAS, FASLG
Hepatitis B (hsa05161) -5.520.019FAS, FASLG
Measles (hsa05162) -5.60.017FAS, FASLG
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Death Receptor SignallingR-HSA-738878.522FAS, FASLG
FasL/ CD95L signalingR-HSA-7515710.662FAS, FASLG
Signal TransductionR-HSA-1625821.782FAS, FASLG

NET-GE enrichment

Term New enriched termICP valueGenes
Death Receptor Signalling (R-HSA-73887) -8.520.0FAS, FASLG
FasL/ CD95L signaling (R-HSA-75157) -10.660.0FAS, FASLG
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182FAS, FASLG
protein binding (GO:0005515) 0.462FAS, FASLG

NET-GE enrichment

Term New enriched termICP valueGenes
phosphatase binding (GO:0019902) NEW4.630.047FAS, FASLG
protein phosphatase binding (GO:0019903) NEW4.930.02FAS, FASLG
ubiquitin protein ligase binding (GO:0031625) NEW4.170.048FAS, FASLG
small conjugating protein ligase binding (GO:0044389) NEW4.150.048FAS, FASLG
tumor necrosis factor receptor superfamily binding (GO:0032813) NEW5.890.002FAS, FASLG
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
negative regulation of apoptotic signaling pathway (GO:2001234) 4.422FAS, FASLG
positive regulation of apoptotic signaling pathway (GO:2001235) 4.582FAS, FASLG
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692FAS, FASLG
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) 5.132FAS, FASLG
regulation of primary metabolic process (GO:0080090) 1.082FAS, FASLG
regulation of metabolic process (GO:0019222) 1.022FAS, FASLG
regulation of apoptotic signaling pathway (GO:2001233) 3.832FAS, FASLG
negative regulation of response to stimulus (GO:0048585) 2.522FAS, FASLG
T cell apoptotic process (GO:0070231) 7.022FAS, FASLG
regulation of response to stimulus (GO:0048583) 1.542FAS, FASLG
signal transduction (GO:0007165) 1.282FAS, FASLG
cell surface receptor signaling pathway (GO:0007166) 2.092FAS, FASLG
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001267) 6.642FAS, FASLG
positive regulation of macromolecule metabolic process (GO:0010604) 1.812FAS, FASLG
response to external biotic stimulus (GO:0043207) 3.132FAS, FASLG
regulation of signal transduction (GO:0009966) 1.842FAS, FASLG
positive regulation of signal transduction (GO:0009967) 2.52FAS, FASLG
response to growth factor (GO:0070848) 4.142FAS, FASLG
positive regulation of molecular function (GO:0044093) 2.232FAS, FASLG
positive regulation of biological process (GO:0048518) 1.22FAS, FASLG
negative regulation of biological process (GO:0048519) 1.332FAS, FASLG
regulation of cell proliferation (GO:0042127) 2.412FAS, FASLG
positive regulation of response to stimulus (GO:0048584) 2.182FAS, FASLG
regulation of macromolecule metabolic process (GO:0060255) 1.082FAS, FASLG
negative regulation of cell death (GO:0060548) 2.952FAS, FASLG
lymphocyte apoptotic process (GO:0070227) 6.842FAS, FASLG
regulation of proteolysis (GO:0030162) 3.22FAS, FASLG
response to organic substance (GO:0010033) 2.22FAS, FASLG
response to biotic stimulus (GO:0009607) 3.092FAS, FASLG
response to external stimulus (GO:0009605) 2.552FAS, FASLG
chemical homeostasis (GO:0048878) 2.972FAS, FASLG
immune system process (GO:0002376) 2.292FAS, FASLG
inflammatory cell apoptotic process (GO:0006925) 7.782FAS, FASLG
positive regulation of metabolic process (GO:0009893) 1.742FAS, FASLG
regulation of signaling (GO:0023051) 1.722FAS, FASLG
response to lipopolysaccharide (GO:0032496) 4.032FAS, FASLG
regulation of apoptotic process (GO:0042981) 2.52FAS, FASLG
regulation of biological process (GO:0050789) 0.452FAS, FASLG
positive regulation of hydrolase activity (GO:0051345) 2.912FAS, FASLG
regulation of peptidase activity (GO:0052547) 3.752FAS, FASLG
biological regulation (GO:0065007) 0.392FAS, FASLG
positive regulation of catalytic activity (GO:0043085) 2.42FAS, FASLG
regulation of gene expression (GO:0010468) 1.372FAS, FASLG
regulation of molecular function (GO:0065009) 1.782FAS, FASLG
regulation of biological quality (GO:0065008) 1.682FAS, FASLG
regulation of developmental process (GO:0050793) 2.12FAS, FASLG
regulation of catalytic activity (GO:0050790) 1.972FAS, FASLG
regulation of cellular process (GO:0050794) 0.52FAS, FASLG
programmed cell death (GO:0012501) 3.12FAS, FASLG
regulation of multicellular organismal process (GO:0051239) 1.872FAS, FASLG
immune response (GO:0006955) 2.862FAS, FASLG
positive regulation of intracellular signal transduction (GO:1902533) 2.952FAS, FASLG
regulation of intracellular signal transduction (GO:1902531) 2.312FAS, FASLG
regulation of hydrolase activity (GO:0051336) 2.532FAS, FASLG
negative regulation of signal transduction (GO:0009968) 2.752FAS, FASLG
response to stimulus (GO:0050896) 1.222FAS, FASLG
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042) 6.22FAS, FASLG
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041) 5.722FAS, FASLG
metabolic process (GO:0008152) 0.582FAS, FASLG
positive regulation of signaling (GO:0023056) 2.412FAS, FASLG
negative regulation of signaling (GO:0023057) 2.652FAS, FASLG
negative regulation of cell communication (GO:0010648) 2.662FAS, FASLG
positive regulation of endopeptidase activity (GO:0010950) 4.782FAS, FASLG
positive regulation of cell communication (GO:0010647) 2.412FAS, FASLG
regulation of cell communication (GO:0010646) 1.732FAS, FASLG
single-organism process (GO:0044699) 0.482FAS, FASLG
extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625) 6.092FAS, FASLG
regulation of protein metabolic process (GO:0051246) 1.932FAS, FASLG
positive regulation of protein metabolic process (GO:0051247) 2.432FAS, FASLG
positive regulation of cellular protein metabolic process (GO:0032270) 2.492FAS, FASLG
leukocyte apoptotic process (GO:0071887) 6.592FAS, FASLG
regulation of cellular metabolic process (GO:0031323) 1.072FAS, FASLG
cellular process (GO:0009987) 0.262FAS, FASLG
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) 4.432FAS, FASLG
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) 4.962FAS, FASLG
cellular chemical homeostasis (GO:0055082) 3.42FAS, FASLG
regulation of cellular protein metabolic process (GO:0032268) 1.992FAS, FASLG
macromolecule metabolic process (GO:0043170) 0.832FAS, FASLG
necroptotic signaling pathway (GO:0097527) 7.942FAS, FASLG
response to molecule of bacterial origin (GO:0002237) 3.992FAS, FASLG
positive regulation of proteolysis (GO:0045862) 3.862FAS, FASLG
cellular homeostasis (GO:0019725) 3.232FAS, FASLG
positive regulation of cellular metabolic process (GO:0031325) 1.812FAS, FASLG
apoptotic signaling pathway (GO:0097190) 4.122FAS, FASLG
extrinsic apoptotic signaling pathway (GO:0097191) 5.162FAS, FASLG
positive regulation of cysteine-type endopeptidase activity (GO:2001056) 4.882FAS, FASLG
homeostatic process (GO:0042592) 2.612FAS, FASLG
positive regulation of cell death (GO:0010942) 3.322FAS, FASLG
cell death (GO:0008219) 3.052FAS, FASLG
regulation of cell death (GO:0010941) 2.432FAS, FASLG
regulation of cysteine-type endopeptidase activity (GO:2000116) 4.372FAS, FASLG
response to lipid (GO:0033993) 3.112FAS, FASLG
positive regulation of apoptotic process (GO:0043065) 3.382FAS, FASLG
organic substance metabolic process (GO:0071704) 0.632FAS, FASLG
regulation of programmed cell death (GO:0043067) 2.492FAS, FASLG
negative regulation of apoptotic process (GO:0043066) 3.042FAS, FASLG
negative regulation of programmed cell death (GO:0043069) 3.022FAS, FASLG
positive regulation of programmed cell death (GO:0043068) 3.382FAS, FASLG
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001269) 6.92FAS, FASLG
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) 5.262FAS, FASLG
regulation of endopeptidase activity (GO:0052548) 3.82FAS, FASLG
apoptotic process (GO:0006915) 3.142FAS, FASLG
single-organism cellular process (GO:0044763) 0.652FAS, FASLG
response to chemical (GO:0042221) 1.982FAS, FASLG
positive regulation of peptidase activity (GO:0010952) 4.72FAS, FASLG
response to oxygen-containing compound (GO:1901700) 2.572FAS, FASLG
regulation of multicellular organismal development (GO:2000026) 2.312FAS, FASLG
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097296) 7.162FAS, FASLG
negative regulation of cellular process (GO:0048523) 1.412FAS, FASLG
positive regulation of cellular process (GO:0048522) 1.32FAS, FASLG

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of extrinsic apoptotic signaling pathway (GO:2001236) -4.690.022FAS, FASLG
T cell apoptotic process (GO:0070231) -7.020.002FAS, FASLG
inflammatory cell apoptotic process (GO:0006925) -7.780.0FAS, FASLG
positive regulation of cysteine-type endopeptidase activity (GO:2001056) -4.880.012FAS, FASLG
protein processing (GO:0016485) NEW4.620.034FAS, FASLG
defense response to Gram-negative bacterium (GO:0050829) NEW5.990.022FAS, FASLG
activation of cysteine-type endopeptidase activity (GO:0097202) NEW7.240.006FAS, FASLG
extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625) -6.090.001FAS, FASLG
regulation of cysteine-type endopeptidase activity (GO:2000116) -4.370.032FAS, FASLG
zymogen activation (GO:0031638) NEW6.330.008FAS, FASLG
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) -4.430.029FAS, FASLG
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) -4.960.01FAS, FASLG
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) -5.260.006FAS, FASLG
regulation of endothelial cell apoptotic process (GO:2000351) NEW5.990.024FAS, FASLG
lymphocyte apoptotic process (GO:0070227) -6.840.0FAS, FASLG
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) NEW5.860.003FAS, FASLG
regulation of immunoglobulin production (GO:0002637) NEW5.860.039FAS, FASLG
extrinsic apoptotic signaling pathway (GO:0097191) -5.160.007FAS, FASLG
positive regulation of endopeptidase activity (GO:0010950) -4.780.013FAS, FASLG
positive regulation of peptidase activity (GO:0010952) -4.70.016FAS, FASLG
protein maturation (GO:0051604) NEW4.480.041FAS, FASLG
leukocyte apoptotic process (GO:0071887) -6.590.0FAS, FASLG
necroptotic signaling pathway (GO:0097527) -7.940.0FAS, FASLG
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
plasma membrane region (GO:0098590) 2.972FAS, FASLG
integral component of membrane (GO:0016021) 1.142FAS, FASLG
external side of plasma membrane (GO:0009897) 4.462FAS, FASLG
intracellular organelle (GO:0043229) 0.512FAS, FASLG
side of membrane (GO:0098552) 4.222FAS, FASLG
intrinsic component of plasma membrane (GO:0031226) 2.532FAS, FASLG
organelle (GO:0043226) 0.42FAS, FASLG
intrinsic component of membrane (GO:0031224) 1.132FAS, FASLG
vesicle (GO:0031982) 1.642FAS, FASLG
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122FAS, FASLG
membrane-bounded organelle (GO:0043227) 0.472FAS, FASLG
nucleus (GO:0005634) 1.072FAS, FASLG
membrane (GO:0016020) 0.682FAS, FASLG
membrane-bounded vesicle (GO:0031988) 1.712FAS, FASLG
perinuclear region of cytoplasm (GO:0048471) 3.352FAS, FASLG
plasma membrane part (GO:0044459) 1.952FAS, FASLG
cell surface (GO:0009986) 3.442FAS, FASLG
membrane region (GO:0098589) 3.952FAS, FASLG
intracellular vesicle (GO:0097708) 2.862FAS, FASLG
integral component of plasma membrane (GO:0005887) 2.572FAS, FASLG
plasma membrane (GO:0005886) 1.392FAS, FASLG
extracellular vesicle (GO:1903561) 1.892FAS, FASLG
extracellular space (GO:0005615) 2.632FAS, FASLG
extracellular organelle (GO:0043230) 1.892FAS, FASLG
intracellular membrane-bounded organelle (GO:0043231) 0.62FAS, FASLG
extracellular exosome (GO:0070062) 1.892FAS, FASLG
membrane raft (GO:0045121) 4.182FAS, FASLG
cell part (GO:0044464) 0.112FAS, FASLG
cytoplasmic part (GO:0044444) 0.822FAS, FASLG
extracellular region (GO:0005576) 2.182FAS, FASLG
cytoplasmic vesicle (GO:0031410) 2.872FAS, FASLG
intracellular part (GO:0044424) 0.282FAS, FASLG
membrane part (GO:0044425) 0.952FAS, FASLG
membrane microdomain (GO:0098857) 4.172FAS, FASLG
extracellular region part (GO:0044421) 1.572FAS, FASLG

NET-GE enrichment

Term New enriched termICP valueGenes
external side of plasma membrane (GO:0009897) -4.460.005FAS, FASLG
membrane raft (GO:0045121) -4.180.005FAS, FASLG
side of membrane (GO:0098552) -4.220.007FAS, FASLG